Nature Reviews Molecular Cell Biology Nature Reviews Molecular Cell Biology is the leading monthly review journal in the field of molecular and cell biology. With its extraordinary breadth and depth of coverage, the journal provides a unique resource of information, opinion and commentary for cutting-edge molecular and cell biology research. All Reviews, Perspectives and Progress articles are carefully commissioned, written by leaders in the field, and subject to rigorous peer review — which results in timely and authoritative articles. In addition, articles are edited and the diagrams redrawn by professional art editors, which makes for highly readable, visually attractive articles that are accessible to specialists and non-specialists alike.
- Molecular mechanisms and biotechnology applications of CRISPR–Cas12a
por Aakash Saha en abril 27, 2026 a las 12:00 amNature Reviews Molecular Cell Biology, Published online: 27 April 2026; doi:10.1038/s41580-026-00969-xThis Review discusses the unique features of the functionally versatile nuclease Cas12a, including allosteric regulation, structural elements controlling guide RNA maturation, target specificity, cis-cleavage and trans-cleavage activities and determinants of off-target cleavage. These features increase the applicability of Cas12a in biotechnology, therapeutics and molecular diagnostics
- The regulation, function and disease relevance of cytoplasmic tRNAspor Robin E. Stanley en abril 21, 2026 a las 12:00 am
Nature Reviews Molecular Cell Biology, Published online: 21 April 2026; doi:10.1038/s41580-026-00963-3This Review discusses the expression and maturation of human cytoplasmic tRNAs and recent insights into their regulation of translation. The authors also explore emerging roles of tRNAs in ribosome-associated quality control and in the integrated stress response and how tRNA dysregulation contributes to human pathologies.
- The PANoptosis hypothesis examinedpor James E. Vince en abril 21, 2026 a las 12:00 am
Nature Reviews Molecular Cell Biology, Published online: 21 April 2026; doi:10.1038/s41580-026-00970-4The concept of PANoptosis describes the simultaneous activation of pyroptosis, apoptosis and necroptosis. This Comment discusses the evidence supporting this hypothesis and proposes criteria to validate PANoptosis.
- Prevailing views of cell senescence overlook its biological complexitypor Nadine Martin en abril 20, 2026 a las 12:00 am
Nature Reviews Molecular Cell Biology, Published online: 20 April 2026; doi:10.1038/s41580-026-00973-1David Bernard and colleagues discuss the complexity of roles of cell senescence and argue that it is crucial to study their contributions to both normal develoment and physiology, and to disease states in order to understand and manipulate cell senescence for therapeutic purposes.
- In-cell chemistry enables discovery of cyclic peptide transcription factor inhibitorspor Andrew Brennan en abril 14, 2026 a las 12:00 am
Nature Reviews Molecular Cell Biology, Published online: 14 April 2026; doi:10.1038/s41580-026-00971-3In this Tools of the Trade article, Brennan (Mason lab) describes a method that enables cyclization and screening of genetically encoded peptides to target the interaction of transcription factors with DNA.