Nature Chemical Biology Nature Chemical Biology is an interdisciplinary journal that publishes the most innovative and important research advances at the interface of chemistry and biology. The journal publishes research from chemists who are applying the principles, language and tools of chemistry to biological systems and from biologists who are interested in understanding biological processes at the molecular level. The scope of the journal covers all areas of contemporary research at the interface of chemistry and biology.
- Regulatory elements on chromatin-associated RNA 15 years beyond RNA epigenetics
por Xiaoyang Dou en abril 28, 2026 a las 12:00 amNature Chemical Biology, Published online: 28 April 2026; doi:10.1038/s41589-026-02207-zThis Perspective introduces the recent development of RNA modifications on chromatin-associated RNAs, discusses how they engage chromatin regulators to modulate chromatin states and direct cellular function and proposes future directions for studying RNA regulatory elements to control gene expression.
- Surveying hypocrealean fungi to identify biocontrol agentsen abril 28, 2026 a las 12:00 am
Nature Chemical Biology, Published online: 28 April 2026; doi:10.1038/s41589-026-02202-4Hypocrealean fungi are the most important source of fungal and insect pest biocontrol agents. By integrating phylogenomics, metabolomics and synthetic biology, we surveyed the biosynthetic capabilities of hypocrealeans to produce a catalog of pest-controlling molecules for sustainable agriculture.
- Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly linepor Zhicheng Guo en abril 24, 2026 a las 12:00 am
Nature Chemical Biology, Published online: 24 April 2026; doi:10.1038/s41589-026-02209-xDecarboxylative condensation is essential for polyketide and fatty acid biosynthesis, yet the mechanism underlying nonelongating modules without this step remains elusive. Here the authors report a condensation-independent intramodular translocation mechanism in trans-acyltransferase polyketide synthases.
- Structural snapshots of self-splicing and circularization of the Anabaena precursor tRNAen abril 24, 2026 a las 12:00 am
Nature Chemical Biology, Published online: 24 April 2026; doi:10.1038/s41589-026-02206-0Group I introns are catalytic RNAs able to perform self-splicing and generate circular RNAs. The cryo-electron microscopy structures of the full-length group I intron of Anabaena now reveal how RNA rearrangements coordinate self-splicing and circularization, thereby enabling structure-guided optimization of circular RNA production.
- Resolving paclitaxel efficacypor Jawdat Al-Bassam en abril 24, 2026 a las 12:00 am
Nature Chemical Biology, Published online: 24 April 2026; doi:10.1038/s41589-026-02208-yNew work using high-resolution cryogenic electron microscopy and biochemistry reveals, at near-atomic resolution, the mechanism whereby a cancer-associated β3-tubulin mutation enhances paclitaxel binding, stabilizes the microtubule lattice and sensitizes cancer cells to paclitaxel.