Nature Cardiovascular Research Nature Cardiovascular Research serves a multidisciplinary audience of scientific, clinical, pharmacological and public health communities by providing a unifying publishing platform that champions and disseminates original and important advances in basic, translational, clinical and public health research in cardiovascular biology and haematology. The journal also serves as a forum for raising challenging questions and exchanging new concepts and ideas, inspiring and stimulating future research directions.
- Antibody–siRNA conjugates enable macrophage-specific osteopontin inhibition to suppress atrial fibrillation
por Na Li en abril 29, 2026 a las 12:00 amNature Cardiovascular Research, Published online: 29 April 2026; doi:10.1038/s44161-026-00808-4Atrial fibrillation is linked to fibrosis and inflammatory macrophage recruitment in atria, with osteopontin (encoded by Spp1) increasing susceptibility by promoting atrial fibrosis and uneven conduction. Research shows that antibody-based silencing of Spp1 in some TREM2+ macrophages reduces fibrotic remodeling and atrial fibrillation risk.
- Mechanisms and therapeutic potential of colchicine in atherosclerotic cardiovascular diseasepor Xinyi Xia en abril 27, 2026 a las 12:00 am
Nature Cardiovascular Research, Published online: 27 April 2026; doi:10.1038/s44161-026-00807-5In this Review, Xia et al. discuss the potential of colchicine as a therapy for atherosclerotic cardiovascular disease, highlighting evidence from clinical trials and mechanistic studies showing its effects on vascular inflammation, plaque stability, and immune and vascular cell function. They also emphasize that mixed results in recent cardiovascular and cerebrovascular trials highlight the need to integrate mechanistic insights with clinical evidence to refine colchicine use and guide precision anti-inflammatory strategies.
- Therapeutic Spp1 silencing in TREM2+ cardiac macrophages suppresses atrial fibrillationpor Noor Momin en abril 23, 2026 a las 12:00 am
Nature Cardiovascular Research, Published online: 23 April 2026; doi:10.1038/s44161-026-00806-6Momin et al. develop an antibody–siRNA conjugate to inhibit the secretion of osteopontin by the TREM2+ macrophages that expand during human atrial fibrillation. In mice, this approach reduced fibrosis and atrial fibrillation vulnerability.
- Three-dimensional visualization of arrhythmogenic substrate in mouse hearts using panoramic optical mapping and micro-computed tomographypor Lea Melki en abril 20, 2026 a las 12:00 am
Nature Cardiovascular Research, Published online: 20 April 2026; doi:10.1038/s44161-026-00803-9Melki, Avula and colleagues combine three-dimensional panoramic optical mapping with micro-computed tomography and deep learning to generate structural and electrical activation data of the heart and elucidate mechanisms of conduction abnormalities.
- PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathypor Yao Wei Lu en abril 20, 2026 a las 12:00 am
Nature Cardiovascular Research, Published online: 20 April 2026; doi:10.1038/s44161-026-00798-3Lu et al. report that PCBP1 safeguards AARS2 alternative splicing in the heart, and that loss of PCBP1 disrupts AARS2 splicing, leading to infantile mitochondrial cardiomyopathy. Loss of cardiac PCBP1 or AARS2 impairs oxidative phosphorylation and activates mitonuclear signaling and the unfolded protein response pathway.